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Variants of concern responsible for SARS-CoV-2 vaccine breakthrough infections from India.

Singh, Urvashi B; Rophina, Mercy; Chaudhry, Rama; Senthivel, Vigneshwar; Bala, Kiran; Bhoyar, Rahul C; Jolly, Bani; Jamshed, Nayer; Imran, Mohamed; Gupta, Ritu; Aggarwal, Praveen; Divakar, Mohit K; Sinha, Subrata; Arvinden, V R; Bajaj, Anjali; Shamnath, Afra; Jain, Abhinav; Scaria, Vinod; Sivasubbu, Sridhar; Guleria, Randeep.

J Med Virol ; 94(4): 1696-1700, 2022 04.

Article in English | MEDLINE | ID: covidwho-1718390

ABSTRACT

Emerging reports of SARS-CoV-2 breakthrough infections entail methodical genomic surveillance for determining the efficacy of vaccines. This study elaborates genomic analysis of isolates from breakthrough infections following vaccination with AZD1222/Covishield and BBV152/Covaxin. Variants of concern B.1.617.2 and B.1.1.7 responsible for cases surge in April-May 2021 in Delhi, were the predominant lineages among breakthrough infections.

Subject(s)

COVID-19/virology , SARS-CoV-2/genetics , Adult , Aged , Aged, 80 and over , COVID-19/epidemiology , COVID-19/prevention & control , COVID-19 Vaccines , ChAdOx1 nCoV-19/administration & dosage , Female , Genome, Viral/genetics , Genomics , Humans , India/epidemiology , Male , Middle Aged , Phylogeny , SARS-CoV-2/immunology , SARS-CoV-2/isolation & purification , Vaccination , Vaccines, Inactivated/administration & dosage , Young Adult

Symptomatic reinfection of SARS-CoV-2 with spike protein variant N440K associated with immune escape.

Rani, Pallavali R; Imran, Mohamed; Lakshmi, Juturu V; Jolly, Bani; Jain, Abhinav; Surekha, Avileli; Senthivel, Vigneshwar; Chandrasekhar, Pulala; Divakar, Mohit K; Srinivasulu, Damam; Bhoyar, Rahul C; Vanaja, P R; Scaria, Vinod; Sivasubbu, Sridhar.

J Med Virol ; 93(7): 4163-4165, 2021 07.

Article in English | MEDLINE | ID: covidwho-1384239

Subject(s)

COVID-19/immunology , Immune Evasion/immunology , Reinfection/immunology , SARS-CoV-2/immunology , Spike Glycoprotein, Coronavirus/immunology , Antibodies, Neutralizing/blood , Antibodies, Viral/blood , Genome, Viral/genetics , Humans , Immune Evasion/genetics , Male , Middle Aged , Reinfection/virology , SARS-CoV-2/genetics , SARS-CoV-2/isolation & purification , Spike Glycoprotein, Coronavirus/genetics

ABSTRACT

Subject(s)

Subject(s)

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